SV2A

Across TCGA cell cohorts, SV2A mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SV2A-associated genes across cancer lineages are CD300LD, C16orf90, and SIGLEC5. Each is linked with SV2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SV2A-to-partner and partner-to-SV2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD300LD grouped by SV2A-low versus SV2A-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SV2A→partner) and Y-score (partner→SV2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CD300LD →	+0.016	+5.614	<.001	.002	3	1
URINARY_TRACT	C16orf90 →	+0.023	+5.087	<.001	.004	3	1
SKIN	SIGLEC5 →	+0.029	+5.415	<.001	.004	3	1
SKIN	AADACL3 →	+0.006	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GRP →	+0.230	+3.392	<.001	.004	3	1
LARGE_INTESTINE	EFCAB12 →	+0.368	+3.125	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

CD300LD by SV2A expression — PANCREAS

Explore this box plot interactively →