SUZ12P1

Across TCGA patient cohorts, SUZ12P1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUZ12P1-associated genes across cancer lineages are ER-alpha, Caspase-7-cleavedD198, and PCNA. Each is linked with SUZ12P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUZ12P1-to-partner and partner-to-SUZ12P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by SUZ12P1-low versus SUZ12P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUZ12P1→partner) and Y-score (partner→SUZ12P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	-1.282	-3.000	.006	.037	3	1
UCEC	Caspase-7-cleavedD198 →	+1.298	+3.019	<.001	.019	3	1
UCEC	PCNA →	+0.381	+3.000	.002	.037	2	1
UCEC	Shc_pY317 →	-0.220	-3.000	.012	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ER-alpha by SUZ12P1 expression — UCEC

Explore this box plot interactively →