SUZ12

Across TCGA patient cohorts, SUZ12 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUZ12-associated genes across cancer lineages are 4E-BP1, p62 Lck ligand, and PCNA. Each is linked with SUZ12 in more than 2 cancer types. Because this analysis shows association rather than direction, both SUZ12-to-partner and partner-to-SUZ12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SUZ12-low versus SUZ12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUZ12→partner) and Y-score (partner→SUZ12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.307	+2.000	.001	.029	3	3
UCEC	p62 Lck ligand →	+0.379	+3.459	.001	<.001	2	3
UCEC	PCNA →	+0.264	+2.807	<.001	.002	3	2
UCEC	STAT3_pY705 →	-0.314	-1.700	<.001	.040	3	2
UCEC	ATM →	-0.757	-2.321	<.001	.001	3	2
UCEC	eEF2 →	+0.386	+2.459	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

4E-BP1 by SUZ12 expression — UCEC

Explore this box plot interactively →