SUZ12

Across TCGA cell cohorts, SUZ12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,514 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SUZ12-associated GO terms across cancer lineages are DNA-templated DNA replication, DNA strand elongation, and Double-strand break repair. Each is linked with SUZ12 in more than 18 cancer types. Because this analysis shows association rather than direction, both SUZ12-to-partner and partner-to-SUZ12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by SUZ12-low versus SUZ12-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SUZ12→partner) and Y-score (partner→SUZ12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNA-templated DNA replication →	+0.107	+0.766	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.169	+1.210	<.001	<.001	3	18
BLOOD_Myeloma	Double-strand break repair →	+0.077	+1.115	<.001	<.001	3	18
SOFT_TISSUE	Sister chromatid cohesion →	+0.129	+0.931	<.001	<.001	3	18
BLOOD_Myeloma	Double-strand break repair via homologous recombination →	+0.085	+1.198	<.001	<.001	3	18
BLOOD_Myeloma	Recombinational repair →	+0.087	+1.198	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,514 associations by consensus.

DNA-templated DNA replication by SUZ12 expression — BLOOD_Myeloma

Explore this box plot interactively →