SUV39H2

Across TCGA patient cohorts, SUV39H2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUV39H2-associated genes across cancer lineages are IGFBP2, Notch1, and p62 Lck ligand. Each is linked with SUV39H2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUV39H2-to-partner and partner-to-SUV39H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by SUV39H2-low versus SUV39H2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUV39H2→partner) and Y-score (partner→SUV39H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.844	-2.321	.009	.035	3	1
UCEC	Notch1 →	+0.190	+2.817	.007	.036	3	1
UCEC	p62 Lck ligand →	+0.436	+2.179	.007	.034	3	1
UCEC	STAT3_pY705 →	-0.392	-2.321	.002	.035	3	1
UCEC	XBP1 →	-0.185	-2.321	.009	.035	3	1
UCEC	4E-BP1 →	+0.405	+3.029	.002	.018	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

IGFBP2 by SUV39H2 expression — UCEC

Explore this box plot interactively →