SUV39H1

Across TCGA pan-cancer cohorts, SUV39H1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SUV39H1 data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SUV39H1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SUV39H1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BLCA, UCS, and HNSC are the cancer types where SUV39H1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.132	0.720	<.001	42	view →
UCS	OS	Median	All	0.102	0.688	<.001	36	view →
HNSC	DFS	Median	All	0.128	0.710	.001	36	view →
UCEC	OS	Median	All	0.962	0.652	.026	24	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	9	view →
LUSC	OS	Median	II,III,IV	0.172	0.732	.003	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SUV39H1–BLCA (OS)

Open the BLCA breakdown →