SUSD6

Across TCGA patient cohorts, SUSD6 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUSD6-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with SUSD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUSD6-to-partner and partner-to-SUSD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SUSD6-low versus SUSD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUSD6→partner) and Y-score (partner→SUSD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.247	-2.222	.020	.011	3	1
UCEC	eIF4E →	+0.176	+2.820	.049	.035	3	1
UCEC	A-Raf_pS299 →	-0.172	-3.584	<.001	.002	3	1
UCEC	IGFBP2 →	-0.631	-1.700	.022	.044	3	1
UCEC	MEK1_p_S217_S221 →	-0.255	-2.321	.028	.034	3	1
UCEC	Notch1 →	+0.162	+3.335	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EGFR_pY1068 by SUSD6 expression — UCEC

Explore this box plot interactively →