SUSD2

Across TCGA patient cohorts, SUSD2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUSD2-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and p62 Lck ligand. Each is linked with SUSD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUSD2-to-partner and partner-to-SUSD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SUSD2-low versus SUSD2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUSD2→partner) and Y-score (partner→SUSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.376	+3.000	.010	.034	3	2
STAD	Cyclin-B1 →	+0.471	+3.169	.039	.019	3	2
UCEC	p62 Lck ligand →	+0.339	+1.884	.009	.030	3	2
STAD	eEF2 →	+0.316	+3.169	.033	.019	3	1
STAD	ER-alpha_pS118 →	+0.094	+3.031	.025	.017	3	1
STAD	ER-alpha →	-0.184	-3.148	.029	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

4E-BP1 by SUSD2 expression — STAD

Explore this box plot interactively →