SUSD1

Across TCGA patient cohorts, SUSD1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUSD1-associated genes across cancer lineages are Caspase-7-cleavedD198, p27_pT198, and 14-3-3_beta. Each is linked with SUSD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SUSD1-to-partner and partner-to-SUSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SUSD1-low versus SUSD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUSD1→partner) and Y-score (partner→SUSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.859	+3.807	<.001	<.001	3	3
UCEC	p27_pT198 →	+0.083	+3.459	.033	.005	3	2
UCEC	14-3-3_beta →	-0.100	-2.295	.006	.005	3	1
UCEC	eEF2 →	+0.339	+3.169	.009	.018	3	1
UCEC	EGFR_pY1068 →	-0.304	-2.700	<.001	.005	3	1
UCEC	ERK2 →	+0.211	+2.459	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by SUSD1 expression — UCEC

Explore this box plot interactively →