SURF6

Across TCGA pan-cancer cohorts, SURF6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SURF6 data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SURF6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SURF6 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where SURF6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.866	0.355	.001	27	view →
CCRCC	DFS	Median	II,III,IV	0.544	0.832	.007	16	view →
LUAD	DFS	Tertile	III,IV	0.729	0.258	.019	8	view →
HNSC	DFS	Tertile	IV	0.505	0.776	.013	6	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SURF6–LSCC (DFS)

Open the LSCC breakdown →