SURF6

Across TCGA patient cohorts, SURF6 mutation is significantly associated with the RNA expression of many other genes, with 1,210 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SURF6-associated genes across cancer lineages are MIR5787, TRAJ37, and RNA5SP115. Each is linked with SURF6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SURF6-to-partner and partner-to-SURF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5787 grouped by SURF6-low versus SURF6-high in SARC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SURF6→partner) and Y-score (partner→SURF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	MIR5787 →	+0.884	+5.477	<.001	.004	3	3
UCEC	TRAJ37 →	+0.716	+2.496	<.001	.001	3	2
LUAD	RNA5SP115 →	+0.275	+5.631	<.001	.004	3	2
SARC	RNA5SP285 →	+0.437	+5.477	<.001	.004	3	2
CESC	MIR4726 →	+0.537	+5.010	<.001	.009	3	2
UCEC	RNU6-22P →	+0.404	+2.936	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,210 associations by consensus.

MIR5787 by SURF6 expression — SARC

Explore this box plot interactively →