SURF6

Across TCGA patient cohorts, SURF6 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SURF6-associated genes across cancer lineages are 4E-BP1, Tuberin, and Cyclin-E2. Each is linked with SURF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SURF6-to-partner and partner-to-SURF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SURF6-low versus SURF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SURF6→partner) and Y-score (partner→SURF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.357	+3.321	.012	.010	3	1
UCEC	Tuberin →	+0.559	+3.321	<.001	.010	2	1
UCEC	Cyclin-E2 →	+0.288	+3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

4E-BP1 by SURF6 expression — UCEC

Explore this box plot interactively →