SURF6

Across TCGA cell cohorts, SURF6 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SURF6-associated genes across cancer lineages are NOBOX, RNASE8, and OR4F15. Each is linked with SURF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SURF6-to-partner and partner-to-SURF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOBOX grouped by SURF6-low versus SURF6-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SURF6→partner) and Y-score (partner→SURF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NOBOX →	+0.020	+5.044	<.001	<.001	3	1
URINARY_TRACT	RNASE8 →	+0.045	+4.584	<.001	.002	3	1
URINARY_TRACT	OR4F15 →	+0.144	+4.217	<.001	.005	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR2Z1 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ELOA3DP →	+0.027	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

NOBOX by SURF6 expression — URINARY_TRACT

Explore this box plot interactively →