SURF4

Across TCGA patient cohorts, SURF4 mutation is significantly associated with the RNA expression of many other genes, with 627 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SURF4-associated genes across cancer lineages are RPS29P32, TXN2, and OIP5. Each is linked with SURF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SURF4-to-partner and partner-to-SURF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P32 grouped by SURF4-low versus SURF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SURF4→partner) and Y-score (partner→SURF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS29P32 →	+0.523	+2.725	<.001	<.001	3	2
UCEC	TXN2 →	+0.394	+4.096	.002	<.001	3	2
UCEC	OIP5 →	+0.714	+3.475	.006	.002	3	2
UCEC	C1QBP →	+0.602	+3.716	.002	<.001	3	2
UCEC	MRPL18 →	+0.447	+2.711	<.001	.003	3	2
UCEC	COPS3 →	+0.490	+3.616	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 627 associations by consensus.

RPS29P32 by SURF4 expression — UCEC

Explore this box plot interactively →