SURF4

Across TCGA patient cohorts, SURF4 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SURF4-associated genes across cancer lineages are eIF4E, PCNA, and Rad50. Each is linked with SURF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SURF4-to-partner and partner-to-SURF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SURF4-low versus SURF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SURF4→partner) and Y-score (partner→SURF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.216	+3.459	.023	.005	3	2
UCEC	PCNA →	+0.245	+2.321	.012	.034	3	2
UCEC	Rad50 →	-0.279	-2.000	.010	.032	3	2
UCEC	ATM →	-0.564	-3.156	.005	.018	3	2
UCEC	EGFR_pY1068 →	-0.302	-2.000	.007	.032	3	1
UCEC	MEK1 →	+0.500	+3.459	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eIF4E by SURF4 expression — UCEC

Explore this box plot interactively →