SURF4

Across TCGA cell cohorts, SURF4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SURF4-associated genes across cancer lineages are ITGAD, GKN1, and SLC15A5. Each is linked with SURF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SURF4-to-partner and partner-to-SURF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by SURF4-low versus SURF4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SURF4→partner) and Y-score (partner→SURF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.015	+4.095	<.001	.009	3	1
LARGE_INTESTINE	GKN1 →	+0.045	+4.095	.002	.009	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	BTNL2 →	+0.081	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ITGAD by SURF4 expression — LARGE_INTESTINE

Explore this box plot interactively →