SURF2

Across TCGA pan-cancer cohorts, SURF2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SURF2 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SURF2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SURF2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where SURF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.628	0.914	.001	16	view →
CCRCC	OS	Tertile	All	0.956	0.798	.028	7	view →
GBM	OS	Median	All	0.897	0.738	.015	3	view →
UCEC	DFS	Median	All	0.848	0.959	.019	2	view →
LSCC	OS	Median	III,IV	0.683	0.988	.031	2	view →
LUAD	OS	Median	All	0.999	0.910	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SURF2–HNSC (DFS)

Open the HNSC breakdown →