SURF1

Across TCGA pan-cancer cohorts, SURF1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SURF1 data layer compared with 20 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SURF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SURF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

PDAC, COAD, and UCEC are the cancer types where SURF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.693	0.885	<.001	22	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
UCEC	OS	Median	II,III,IV	1.000	0.638	.014	6	view →
LUAD	OS	Quartile	All	0.847	0.649	.037	2	view →
GBM	OS	Median	All	0.893	0.737	.028	1	view →
HNSC	DFS	Median	IV	0.765	0.561	.044	1	view →
LSCC	DFS	Median	All	0.905	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SURF1–PDAC (DFS)

Open the PDAC breakdown →