SURF1

Across TCGA patient cohorts, SURF1 mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SURF1-associated genes across cancer lineages are POM121C, RNA5SP414, and C17orf98. Each is linked with SURF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SURF1-to-partner and partner-to-SURF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POM121C grouped by SURF1-low versus SURF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SURF1→partner) and Y-score (partner→SURF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POM121C →	+0.803	+3.223	<.001	.009	3	1
UCEC	RNA5SP414 →	+0.728	+2.670	<.001	.009	3	1
UCEC	C17orf98 →	+0.533	+3.298	.001	.008	3	1
UCEC	MIR7976 →	+0.468	+2.868	.001	.006	3	1
UCEC	MIR6894 →	+0.686	+2.496	.001	.009	3	1
UCEC	MIR548AW →	+0.463	+4.245	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

POM121C by SURF1 expression — UCEC

Explore this box plot interactively →