SUPV3L1

Across TCGA patient cohorts, SUPV3L1 mutation is significantly associated with the RNA expression of many other genes, with 1,537 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUPV3L1-associated genes across cancer lineages are OR51T1, MIR4540, and PSMD6. Each is linked with SUPV3L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUPV3L1-to-partner and partner-to-SUPV3L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51T1 grouped by SUPV3L1-low versus SUPV3L1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUPV3L1→partner) and Y-score (partner→SUPV3L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OR51T1 →	+0.042	+5.090	<.001	<.001	3	2
PRAD	MIR4540 →	+0.398	+7.939	<.001	.008	3	2
SKCM	PSMD6 →	+0.517	+3.198	.007	.009	3	2
UCEC	CDCA2 →	+0.645	+2.823	.003	.001	3	2
SKCM	PSMD12 →	+0.608	+3.198	.009	.009	3	2
UCEC	DCLRE1A →	+0.423	+1.947	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,537 associations by consensus.

OR51T1 by SUPV3L1 expression — HNSC

Explore this box plot interactively →