SUPV3L1

Across TCGA patient cohorts, SUPV3L1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUPV3L1-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, A-Raf_pS299, and ERK2. Each is linked with SUPV3L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUPV3L1-to-partner and partner-to-SUPV3L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by SUPV3L1-low versus SUPV3L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUPV3L1→partner) and Y-score (partner→SUPV3L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.542	+1.884	.009	.030	3	2
UCEC	A-Raf_pS299 →	-0.152	-3.584	.002	.002	3	1
UCEC	ERK2 →	+0.167	+1.807	.036	.027	3	1
UCEC	FoxM1 →	+0.297	+3.000	.005	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.146	-2.321	.004	.006	3	1
UCEC	INPP4B →	-0.267	-2.999	.045	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Acetyl-a-Tubulin-Lys40 by SUPV3L1 expression — UCEC

Explore this box plot interactively →