SUN5

Across TCGA pan-cancer cohorts, SUN5 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SUN5 data layer compared with 14 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SUN5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SUN5 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

ESCA, LIHC, and PRAD are the cancer types where SUN5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.191	0.528	.007	12	view →
LIHC	OS	Median	All	0.015	0.784	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	OS	Median	III,IV	1.000	0.385	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SUN5–ESCA (DFS)

Open the ESCA breakdown →