SUN5

Across TCGA patient cohorts, SUN5 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUN5-associated genes across cancer lineages are ERK2, PCNA, and Axl. Each is linked with SUN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUN5-to-partner and partner-to-SUN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SUN5-low versus SUN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUN5→partner) and Y-score (partner→SUN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.263	+2.584	.003	.011	3	2
UCEC	PCNA →	+0.311	+2.584	.001	.011	3	2
UCEC	Axl →	-0.204	-2.423	.041	.020	3	2
SKCM	Myosin-IIa_pS1943 →	-0.364	-2.567	.005	.011	3	1
SKCM	p27_pT157 →	+0.199	+2.186	<.001	.032	3	1
SKCM	p90 RSK →	-0.269	-3.000	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ERK2 by SUN5 expression — UCEC

Explore this box plot interactively →