SUN3

Across TCGA patient cohorts, SUN3 mutation is significantly associated with the RNA expression of many other genes, with 1,258 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUN3-associated genes across cancer lineages are RN7SL291P, SKA1, and C18orf54. Each is linked with SUN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SUN3-to-partner and partner-to-SUN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL291P grouped by SUN3-low versus SUN3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUN3→partner) and Y-score (partner→SUN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL291P →	+0.135	+3.953	<.001	.002	3	3
UCEC	SKA1 →	+0.733	+2.332	.001	.003	3	3
UCEC	C18orf54 →	+0.573	+2.321	.005	.006	3	3
SKCM	RNU7-141P →	+0.307	+2.931	.006	.006	3	3
UCEC	NOL12 →	+0.381	+3.032	.001	<.001	3	2
UCEC	RPS29P32 →	+0.453	+2.221	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,258 associations by consensus.

RN7SL291P by SUN3 expression — HNSC

Explore this box plot interactively →