SUN3

Across TCGA patient cohorts, SUN3 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUN3-associated genes across cancer lineages are PAI-1, p70-S6K, and MEK1. Each is linked with SUN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SUN3-to-partner and partner-to-SUN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by SUN3-low versus SUN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUN3→partner) and Y-score (partner→SUN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAI-1 →	+0.399	+2.321	.012	.033	3	3
LUAD	p70-S6K →	+0.265	+3.169	.017	.019	3	1
UCEC	MEK1 →	+0.364	+2.321	.032	.034	3	1
UCEC	PDCD4 →	-0.750	-3.312	<.001	.010	3	1
UCEC	PR →	-0.273	-3.700	.019	.001	2	2
UCEC	Annexin-1 →	+0.624	+3.019	.011	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PAI-1 by SUN3 expression — UCEC

Explore this box plot interactively →