SUN3

Across TCGA cell cohorts, SUN3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SUN3-associated genes across cancer lineages are DMRTB1, STRA8, and SIGLEC7. Each is linked with SUN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUN3-to-partner and partner-to-SUN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMRTB1 grouped by SUN3-low versus SUN3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUN3→partner) and Y-score (partner→SUN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DMRTB1 →	+0.005	+4.472	<.001	.001	3	1
LUNG_NSCLC_LUAD	STRA8 →	+0.433	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	SIGLEC7 →	+0.048	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR13C8 →	+0.021	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

DMRTB1 by SUN3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →