SUN2

Across TCGA pan-cancer cohorts, SUN2 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SUN2 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SUN2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SUN2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, LSCC, and CCRCC are the cancer types where SUN2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.893	0.559	.002	26	view →
LSCC	DFS	Quartile	II,III,IV	0.428	0.929	.004	12	view →
CCRCC	DFS	Median	III,IV	0.853	0.567	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SUN2–LUAD (DFS)

Open the LUAD breakdown →