SUN2

Across TCGA patient cohorts, SUN2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUN2-associated genes across cancer lineages are FoxM1, MSH2, and MSH6. Each is linked with SUN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUN2-to-partner and partner-to-SUN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SUN2-low versus SUN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUN2→partner) and Y-score (partner→SUN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.195	+1.765	.045	.014	3	2
UCEC	MSH2 →	-0.294	-1.848	<.001	.049	3	2
UCEC	MSH6 →	-0.461	-2.584	<.001	.010	3	2
UCEC	ATM →	-0.569	-1.765	<.001	.014	3	2
UCEC	4E-BP1 →	+0.285	+3.169	.005	.018	3	2
UCEC	EGFR_pY1068 →	-0.225	-1.807	.016	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

FoxM1 by SUN2 expression — UCEC

Explore this box plot interactively →