SUN2

Across TCGA cell cohorts, SUN2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SUN2-associated genes across cancer lineages are BPIFB6, OR2T4, and ZSWIM2. Each is linked with SUN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUN2-to-partner and partner-to-SUN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by SUN2-low versus SUN2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUN2→partner) and Y-score (partner→SUN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BPIFB6 →	+0.012	+5.029	.001	.006	3	1
LUNG_SCLC	OR2T4 →	+0.083	+5.643	<.001	.002	3	1
BLOOD_Leukemia	ZSWIM2 →	+0.033	+4.409	<.001	.005	3	1
BLOOD_Leukemia	KIR3DL1 →	+0.033	+4.276	<.001	.007	3	1
BLOOD_Leukemia	GIMD1 →	+0.039	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OC90 →	+0.012	+5.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

BPIFB6 by SUN2 expression — LUNG_SCLC

Explore this box plot interactively →