SUMO4

Across TCGA patient cohorts, SUMO4 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUMO4-associated genes across cancer lineages are RNA5SP31, HSPE1-MOB4, and RNA5SP414. Each is linked with SUMO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUMO4-to-partner and partner-to-SUMO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP31 grouped by SUMO4-low versus SUMO4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUMO4→partner) and Y-score (partner→SUMO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP31 →	+0.344	+7.816	<.001	.008	3	2
UCEC	HSPE1-MOB4 →	+0.197	+3.799	.007	.003	3	1
UCEC	RNA5SP414 →	+0.732	+3.255	<.001	.003	3	1
UCEC	MIR6766 →	+0.474	+3.621	<.001	.004	3	1
UCEC	IGKV1OR-2 →	+0.342	+3.130	<.001	.003	3	1
UCEC	KIR3DL1 →	+0.291	+3.718	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

RNA5SP31 by SUMO4 expression — SKCM

Explore this box plot interactively →