SUMO1

Across TCGA patient cohorts, SUMO1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUMO1-associated genes across cancer lineages are Ku80, MIG-6, and 4E-BP1. Each is linked with SUMO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUMO1-to-partner and partner-to-SUMO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SUMO1-low versus SUMO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUMO1→partner) and Y-score (partner→SUMO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.371	+2.820	.010	.036	3	1
UCEC	MIG-6 →	+0.125	+2.820	.040	.036	3	1
UCEC	4E-BP1 →	+0.483	+2.837	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Ku80 by SUMO1 expression — UCEC

Explore this box plot interactively →