SUMO1

Across TCGA cell cohorts, SUMO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,657 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SUMO1-associated GO terms across cancer lineages are Positive regulation of plasma cell differentiation, Medulla oblongata development, and Pons development. Each is linked with SUMO1 in more than 12 cancer types. Because this analysis shows association rather than direction, both SUMO1-to-partner and partner-to-SUMO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of plasma cell differentiation grouped by SUMO1-low versus SUMO1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SUMO1→partner) and Y-score (partner→SUMO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of plasma cell differentiation →	-0.145	-0.683	.002	.003	3	13
LUNG_SCLC	Medulla oblongata development →	+0.160	+0.558	.008	.002	3	12
LUNG_SCLC	Pons development →	+0.107	+0.484	.002	.003	3	12
OESOPHAGUS	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.099	+0.683	.003	.004	3	12
OVARY	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.106	+0.452	<.001	<.001	3	11
BLOOD_Myeloma	Somatic recombination of immunoglobulin gene segments →	+0.065	+0.797	.009	.006	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,657 associations by consensus.

Positive regulation of plasma cell differentiation by SUMO1 expression — URINARY_TRACT

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