SUMF2

Across TCGA patient cohorts, SUMF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,153 significant associations in total. THCA shows the largest number of these associations.

The most reproducible SUMF2-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgA isotypes, Peroxisomal transport, and Protein import into peroxisome matrix, receptor recycling. Each is linked with SUMF2 in more than 24 cancer types. Because this analysis shows association rather than direction, both SUMF2-to-partner and partner-to-SUMF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgA isotypes grouped by SUMF2-low versus SUMF2-high in UCS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SUMF2→partner) and Y-score (partner→SUMF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	Positive regulation of isotype switching to IgA isotypes →	+0.087	+1.000	<.001	<.001	3	25
THYM	Peroxisomal transport →	+0.053	+0.624	<.001	<.001	3	21
THYM	Protein import into peroxisome matrix, receptor recycling →	+0.055	+0.593	<.001	<.001	3	21
THYM	Protein import into peroxisome matrix, substrate release →	+0.079	+0.780	<.001	<.001	3	20
THYM	Protein import into peroxisome matrix →	+0.055	+0.603	<.001	<.001	3	19
ACC	Peroxisome organization →	+0.052	+1.613	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,153 associations by consensus.

Positive regulation of isotype switching to IgA isotypes by SUMF2 expression — UCS

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