SUMF1

Across TCGA pan-cancer cohorts, SUMF1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SUMF1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SUMF1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SUMF1 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LUAD, HNSC, and LSCC are the cancer types where SUMF1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SUMF1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+0.450	<.001	8	view →
HNSC	Male	III,IV	+0.235	<.001	8	view →
LSCC	Male	III,IV	+0.426	<.001	7	view →
PDAC	Female	All	+0.579	<.001	6	view →
CCRCC	Male	All	−0.184	<.001	6	view →
COAD	Female	All	+0.244	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SUMF1–LUAD

Open the LUAD breakdown →