SUMF1

Across TCGA patient cohorts, SUMF1 mutation is significantly associated with the RNA expression of many other genes, with 3,391 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUMF1-associated genes across cancer lineages are MIR3927, RNA5SP386, and MIR764. Each is linked with SUMF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUMF1-to-partner and partner-to-SUMF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3927 grouped by SUMF1-low versus SUMF1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUMF1→partner) and Y-score (partner→SUMF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR3927 →	+0.513	+5.151	<.001	.007	3	2
CESC	RNA5SP386 →	+0.388	+4.320	.001	.007	3	2
HNSC	MIR764 →	+0.578	+7.954	<.001	.008	3	1
HNSC	MIR4307 →	+0.582	+7.954	<.001	.008	3	1
UCEC	BTBD10 →	+0.646	+3.839	<.001	<.001	3	1
UCEC	LIN7C →	+0.596	+3.815	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,391 associations by consensus.

MIR3927 by SUMF1 expression — LUSC

Explore this box plot interactively →