SUMF1

Across TCGA patient cohorts, SUMF1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUMF1-associated genes across cancer lineages are JNK_pT183_Y185, ERK2, and MEK1. Each is linked with SUMF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUMF1-to-partner and partner-to-SUMF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SUMF1-low versus SUMF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUMF1→partner) and Y-score (partner→SUMF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.171	-2.321	.019	.034	3	2
UCEC	ERK2 →	+0.241	+3.459	.004	.005	3	1
UCEC	MEK1 →	+0.423	+3.906	.008	<.001	3	1
UCEC	MSH2 →	-0.340	-3.143	<.001	.018	3	1
UCEC	p21 →	+0.205	+2.115	.014	.019	3	1
UCEC	PCNA →	+0.368	+2.584	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

JNK_pT183_Y185 by SUMF1 expression — UCEC

Explore this box plot interactively →