SULT2A1

Across TCGA pan-cancer cohorts, SULT2A1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SULT2A1 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SULT2A1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SULT2A1 expression acts as an unfavorable survival marker, although some lineages such as LIHC and LUSC show a favorable association.

ESCA, KIRC, and COAD are the cancer types where SULT2A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Tertile	All	0.531	0.768	.001	54	view →
KIRC	DFS	Quartile	III,IV	0.608	0.796	.003	46	view →
COAD	OS	Tertile	III,IV	0.384	0.759	.001	42	view →
MESO	DFS	Tertile	IV	0.114	0.437	.002	36	view →
UVM	DFS	Tertile	III,IV	0.132	0.722	.002	27	view →
LIHC	DFS	Quartile	All	0.614	0.421	.002	27	view →
CHOL	DFS	Median	II,III,IV	0.107	0.546	.008	25	view →
LUSC	OS	Median	II,III,IV	0.716	0.584	.022	21	view →
ACC	DFS	Quartile	II,III,IV	0.627	0.128	.006	19	view →
SCLC	DFS	Tertile	III,IV	0.137	0.756	.025	18	view →
PAAD	OS	Quartile	All	0.387	0.638	.001	15	view →
SARC	OS	Tertile	All	0.697	0.867	.002	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SULT2A1–ESCA (OS)

Open the ESCA breakdown →