Across TCGA pan-cancer cohorts, SULT1C4 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SULT1C4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SULT1C4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SULT1C4 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and PDAC are the cancer types where SULT1C4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SULT1C4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−1.186	<.001	8	view →
LSCC	Female	All	−0.775	<.001	7	view →
PDAC	All	All	−0.855	.022	1	view →
CCRCC	All	All	+0.222	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SULT1C4 RNA expression & survival · all SULT1C4 data types