Across TCGA patient cohorts, SULF2 mutation is significantly associated with the RNA expression of many other genes, with 3,943 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SULF2-associated genes across cancer lineages are GPR3, PIMREG, and GLOD4. Each is linked with SULF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SULF2-to-partner and partner-to-SULF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SULF2→partner) and Y-score (partner→SULF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GPR3 →	+0.825	+3.249	<.001	.008	3	4
UCEC	PIMREG →	+0.882	+2.343	<.001	<.001	3	4
UCEC	GLOD4 →	+0.435	+2.332	.002	<.001	3	4
UCEC	REEP4 →	+0.470	+2.332	.002	<.001	3	4
UCEC	UBE2S →	+0.732	+3.480	<.001	.002	3	3
SKCM	B4GALT2 →	+0.384	+3.195	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,943 associations by consensus.

Exploration

SULF2 survival (RNA) · tumor vs normal (RNA) · all SULF2 data types