Across TCGA patient cohorts, SULF2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SULF2-associated genes across cancer lineages are IRS1, p27_pT157, and Stathmin. Each is linked with SULF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SULF2-to-partner and partner-to-SULF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SULF2→partner) and Y-score (partner→SULF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IRS1 →	+0.134	+3.025	.028	.018	3	3
COAD	p27_pT157 →	+0.200	+3.008	.008	.019	3	3
UCEC	Stathmin →	+0.183	+2.321	.001	.006	3	3
LUAD	EGFR_pY1068 →	-0.468	-2.321	.041	.035	3	2
LUAD	GATA3 →	+0.167	+3.000	.007	.034	3	2
COAD	INPP4B →	-0.504	-2.991	.009	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

SULF2 survival (RNA) · tumor vs normal (RNA) · all SULF2 data types