SULF1

Across TCGA patient cohorts, SULF1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SULF1-associated genes across cancer lineages are ATM, TFRC, and Caspase-7-cleavedD198. Each is linked with SULF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SULF1-to-partner and partner-to-SULF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SULF1-low versus SULF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SULF1→partner) and Y-score (partner→SULF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.433	-2.188	<.001	<.001	3	4
UCEC	TFRC →	+0.390	+1.129	.003	.006	3	3
COAD	Caspase-7-cleavedD198 →	+1.120	+3.016	<.001	.018	3	3
UCEC	Cyclin-B1 →	+0.527	+2.137	<.001	<.001	3	3
UCEC	Di-Ras3 →	-0.077	-1.649	.042	.009	3	3
SKCM	Caveolin-1 →	-0.584	-1.874	.010	.047	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ATM by SULF1 expression — UCEC

Explore this box plot interactively →