SULF1

Across TCGA cell cohorts, SULF1 mutation is significantly associated with the RNA expression of many other genes, with 942 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SULF1-associated genes across cancer lineages are ACER1, COQ9, and OR1L4. Each is linked with SULF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SULF1-to-partner and partner-to-SULF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by SULF1-low versus SULF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SULF1→partner) and Y-score (partner→SULF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.059	+2.408	.001	<.001	3	2
LARGE_INTESTINE	COQ9 →	+0.441	+3.321	.006	.003	3	2
BLOOD_Lymphoma	OR1L4 →	+0.031	+4.459	<.001	.001	3	2
BLOOD_Myeloma	C9orf50 →	+0.039	+3.285	<.001	.009	3	1
BLOOD_Myeloma	CXorf51A →	+0.455	+3.716	.006	.005	3	1
SOFT_TISSUE	OR2B2 →	+0.065	+4.882	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 942 associations by consensus.

ACER1 by SULF1 expression — LARGE_INTESTINE

Explore this box plot interactively →