SUGCT

Across TCGA patient cohorts, SUGCT mutation is significantly associated with the RNA expression of many other genes, with 1,534 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUGCT-associated genes across cancer lineages are NOL12, CIAO2B, and MVD. Each is linked with SUGCT in more than 1 cancer types. Because this analysis shows association rather than direction, both SUGCT-to-partner and partner-to-SUGCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOL12 grouped by SUGCT-low versus SUGCT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUGCT→partner) and Y-score (partner→SUGCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NOL12 →	+0.373	+2.823	.001	.001	3	2
UCEC	CIAO2B →	+0.402	+3.108	.005	<.001	3	2
UCEC	MVD →	+0.612	+3.633	.001	.001	3	2
UCEC	SLC3A2 →	+0.651	+1.949	<.001	.009	3	2
UCEC	SAC3D1 →	+0.565	+3.616	.002	.001	3	2
UCEC	REEP4 →	+0.661	+3.721	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,534 associations by consensus.

NOL12 by SUGCT expression — UCEC

Explore this box plot interactively →