SUFU

Across TCGA pan-cancer cohorts, SUFU mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SUFU data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SUFU mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SUFU expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where SUFU mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.854	1.000	.013	14	view →
UCEC	OS	Tertile	II,III,IV	0.554	1.000	.022	8	view →
LUAD	OS	Median	All	0.772	0.910	.027	6	view →
PDAC	DFS	Median	IV	0.934	0.238	.017	6	view →
OV	DFS	Median	All	0.839	1.000	.017	4	view →
HNSC	DFS	Quartile	IV	0.935	0.617	.033	2	view →
LSCC	OS	Median	All	0.920	0.817	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SUFU–CCRCC (DFS)

Open the CCRCC breakdown →