SUDS3

Across TCGA patient cohorts, SUDS3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUDS3-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with SUDS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUDS3-to-partner and partner-to-SUDS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SUDS3-low versus SUDS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUDS3→partner) and Y-score (partner→SUDS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.104	-3.558	.008	.002	3	1
UCEC	EGFR_pY1068 →	-0.331	-3.169	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.156	-3.584	<.001	.002	3	1
UCEC	FoxM1 →	+0.225	+2.000	.026	.010	3	1
UCEC	GATA6 →	-0.149	-3.155	.013	.018	3	1
UCEC	ACC1 →	+0.294	+3.013	.039	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

14-3-3_beta by SUDS3 expression — UCEC

Explore this box plot interactively →