SUCO

Across TCGA cell cohorts, SUCO mutation is significantly associated with the RNA expression of many other genes, with 425 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SUCO-associated genes across cancer lineages are SDHAF4, CRLF3, and OR13C9. Each is linked with SUCO in more than 1 cancer types. Because this analysis shows association rather than direction, both SUCO-to-partner and partner-to-SUCO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SDHAF4 grouped by SUCO-low versus SUCO-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUCO→partner) and Y-score (partner→SUCO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SDHAF4 →	+0.549	+2.043	.004	.008	3	2
LARGE_INTESTINE	CRLF3 →	+0.498	+2.743	.003	.001	3	2
PANCREAS	OR13C9 →	+0.023	+5.614	<.001	.002	3	1
PANCREAS	OPCML →	+0.006	+5.000	<.001	.006	3	1
LUNG_SCLC	RXFP2 →	+0.252	+4.044	<.001	.009	3	1
LUNG_SCLC	PRR20B →	+0.022	+4.269	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 425 associations by consensus.

SDHAF4 by SUCO expression — LARGE_INTESTINE

Explore this box plot interactively →