SUCLG2

Across TCGA patient cohorts, SUCLG2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUCLG2-associated genes across cancer lineages are INPP4B, JNK2, and Notch1. Each is linked with SUCLG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUCLG2-to-partner and partner-to-SUCLG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SUCLG2-low versus SUCLG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUCLG2→partner) and Y-score (partner→SUCLG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.391	-3.700	.005	.001	3	1
UCEC	JNK2 →	+0.196	+2.115	.024	.019	3	1
UCEC	Notch1 →	+0.189	+2.183	.002	.033	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.542	-3.459	.005	.005	3	1
UCEC	p62 Lck ligand →	+0.301	+2.807	.034	.003	3	1
UCEC	PCNA →	+0.196	+2.321	.037	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

INPP4B by SUCLG2 expression — UCEC

Explore this box plot interactively →