SUCLA2

Across TCGA cell cohorts, SUCLA2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SUCLA2-associated genes across cancer lineages are SPINK9, ADH1B, and OR4A47. Each is linked with SUCLA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUCLA2-to-partner and partner-to-SUCLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK9 grouped by SUCLA2-low versus SUCLA2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUCLA2→partner) and Y-score (partner→SUCLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SPINK9 →	+0.043	+5.321	<.001	.005	3	2
LARGE_INTESTINE	ADH1B →	+0.063	+3.726	<.001	.004	3	1
LARGE_INTESTINE	OR4A47 →	+0.015	+4.022	<.001	.006	3	1
CNS	TEX55 →	+0.049	+5.321	<.001	.005	3	1
CNS	OR11H6 →	+0.021	+5.321	<.001	.005	3	1
CNS	OR5M8 →	+0.022	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SPINK9 by SUCLA2 expression — CNS

Explore this box plot interactively →