SUB1

Across TCGA pan-cancer cohorts, SUB1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SUB1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SUB1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SUB1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where SUB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.831	0.406	.003	49	view →
LUAD	OS	Median	III,IV	0.879	0.278	<.001	46	view →
HNSC	DFS	Tertile	II,III,IV	0.892	1.000	.006	13	view →
UCEC	OS	Tertile	II,III,IV	0.682	1.000	.045	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SUB1–CCRCC (DFS)

Open the CCRCC breakdown →