SUB1

Across TCGA pan-cancer cohorts, SUB1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SUB1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SUB1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SUB1 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

HNSC, LSCC, and LUAD are the cancer types where SUB1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SUB1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.539	<.001	11	view →
LSCC	Female	II,III,IV	+1.049	<.001	9	view →
LUAD	All	III,IV	+0.694	<.001	9	view →
OV	All	All	+0.538	.007	2	view →
CCRCC	Female	All	−0.133	.016	2	view →
COAD	Female	All	+0.140	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SUB1–HNSC

Open the HNSC breakdown →